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Building a bypass the natural way

Novel therapies could replace surgical interventions

Munich, 07/27/2011

The body can induce the growth of collateral vessels in response to local reductions in blood flow caused by the narrowing of arteries. In principle, this process could be induced in order to substitute for complicated bypass operations. Impaired circulation due to occlusion of arteries in the lower limbs, for instance – could be also treated in this way, if the body could be purposely stimulated to produce functional collateral vessels. In a book entitled “Arteriogenesis – Molecular Regulation, Pathophysiology and Therapeutics I”, Privatdozentin Dr. Elisabeth Deindl of the Walter-Brendel Center for Experimental Medicine at LMU and Professor Wolfgang Schaper, formerly Director of the Max Planck Institute for Heart and Lung Research in Bad Nauheim, present an overview of the present state of research on the topic. The book, which is primarily addressed to a specialist readership, brings together contributions by eminent experts in the field. The essays deal with all aspects of the induction and growth of collateral arterial networks. “Some of the approaches taken have turned out to be dead ends, others look quite promising,” says Schaper. “That is why, in the book, we placed such emphasis on highlighting the long-term perspective for the field and its future potential. ”The first clinical studies are already underway. Particularly in recent years, research in this area has made great strides, partly because faster and more sensitive analytical methods have become available,” says Deindl. “We hope that the new findings can soon be translated into clinical practice. The ability to enhance natural bypass formation would lead to significant improvements in quality of life for patients.” (MPI)

Publication:
Arteriogenesis - Molecular Regulation, Pathophysiology and Therapeutics I
Elisabeth Deindl (Hg.), Wolfgang Schaper (Hg.)
Published by Shaker Verlag, 210 pp, February 2011
ISBN: 978-3832297978

Contact:
PD Dr. Elisabeth Deindl
Phone: +49 89 / 2180-76504
Fax: +49  89 / 2180-76503
Email: elisabeth.deindl@med.uni-muenchen.de
Web: www.wbex.med.uni-muenchen.de

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