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Autoimmune diseases

Roquin’s mode of action revealed

München, 07/16/2014

An interdisciplinary team has solved the molecular structure of the protein roquin, and revealed how it binds to its RNA targets.

Research teams at the Helmholtz Center Munich, LMU Munich and the Technical University of Munich (TUM) have taken an important step to understanding the molecular mechanisms that underlie autoimmune diseases. They solved the three-dimensional structure of the roquin protein when bound to messenger ribonucleic acid (mRNA) molecules. The results revealed that the range of functionally important roquin binding partners is much wider than previously assumed. The new findings appear in the journal Nature Structural & Molecular Biology.